Name: GHK-Cu
Price: 54.99 EUR
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How does GHK-Cu work?

GHK-Cu stimulates collagen synthesis in fibroblast cultures and regulates the activity of metalloproteinases — enzymes involved in extracellular matrix remodeling. The copper-binding properties enable unique biological activities distinct from other bioactive peptides.

Research indicates GHK-Cu may upregulate antioxidant enzymes including superoxide dismutase (SOD) and glutathione peroxidase. It also appears to modulate inflammatory cytokines and reduce oxidative stress markers.

Microarray studies suggest GHK-Cu influences the expression of numerous genes involved in tissue repair, inflammation, and cellular stress responses, generating interest in regenerative medicine research.

Benefits

Collagen Synthesis: Stimulates collagen production in fibroblast cultures and regulates extracellular matrix remodeling

Antioxidant Properties: Upregulates antioxidant enzymes including SOD and glutathione peroxidase

Wound Healing: Accelerates wound healing processes and tissue regeneration in preclinical models

Gene Expression: Influences expression of genes involved in tissue repair and cellular stress responses

Anti-Inflammatory: Modulates inflammatory cytokines and reduces oxidative stress markers

Side Effects

GHK-Cu is generally considered safe and well tolerated when used in research settings. However, as with any substance, there is a potential for side effects, particularly when used at high concentrations or for prolonged periods.

Skin Sensitivity: Mild irritation or sensitivity at application site reported in some studies
Discoloration: Temporary blue-green discoloration possible due to copper content
Allergic Reactions: Rare allergic reactions in subjects with copper sensitivity
Limited Systemic Data: Long-term systemic effects not fully characterized in research

It's important to note that the safety and efficacy of GHK-Cu for human use have not been fully established, and more research is needed to determine the long-term effects of this peptide complex.

Summary

GHK-Cu (glycyl-L-histidyl-L-lysine:copper(II)) is a naturally occurring tripeptide first isolated from human plasma by Dr. Loren Pickart in 1973. Plasma levels of GHK-Cu decline with age, which has driven research interest in its potential biological roles.

GHK-Cu has been the subject of extensive research spanning wound healing, skin biology, and tissue regeneration. Its copper-binding properties enable unique biological activities.

Certificate of Analysis (COA) available upon request. Each batch is tested via HPLC for purity and Mass Spectrometry for identity confirmation.

References

1Pickart L, et al. "GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration" BioMed Research International. 2015. doi:10.1155/2015/648108

2Pickart L, Margolina A. "Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data" International Journal of Molecular Sciences. 2018. doi:10.3390/ijms19071987

Resource

All products on this site are for research and development use only. Products are not for human consumption of any kind. The statements made on this website have not been evaluated by the US Food and Drug Administration or the European Medicines Agency. Products are not intended to diagnose, treat, cure, or prevent any disease.

Molecular Formula	C14H23CuN6O4
CAS	49557-75-7
Molar Mass	403.92 g/mol
Amino Acid Sequence	Gly-His-Lys:Cu(II)
Synonyms	Copper Peptide, Glycyl-L-histidyl-L-lysine:copper(II)
Solubility	Soluble in water
Organoleptic Profile	Blue powder (copper complexation)
Physical Form	Lyophilized powder

GHK-Cu