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This product is intended solely for use as a research chemical in vitro and laboratory experimentation by licensed, qualified professionals.
TB-500
45,00 €
TB-500 is a synthetic analog of Thymosin Beta-4, a naturally occurring 43-amino acid peptide. Researched for its role in cell migration, cytoskeletal regulation, and tissue repair processes. 10mg lyophilized powder, ≥99% purity.
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TB-500—
45,00 €
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≥99% Purity
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Characteristics
| Molecular Formula | C212H350N56O78S |
| CAS | 77591-33-4 |
| Molar Mass | 4963.44 g/mol |
| Synonyms | Thymosin Beta-4 Fragment, Tβ4 |
| Solubility | Soluble in water |
| Organoleptic Profile | White to off-white powder |
| Physical Form | Lyophilized powder |
How does TB-500 work?
TB-500 binds to and sequesters G-actin monomers, regulating actin polymerization and cytoskeletal dynamics. This mechanism is central to cell movement, making TB-500 valuable for research on wound healing, immune cell trafficking, and tissue remodeling.
Studies indicate TB-500 may modulate inflammatory cytokines including TNF-α and IL-6, with implications for research into inflammatory conditions and tissue repair following injury.
Preclinical models have investigated TB-500's potential effects on cardiac tissue, particularly in the context of ischemic injury and vascular function.
References
- 1Goldstein AL, et al. "Thymosin β4: actin-sequestering protein moonlights to repair injured tissues" Trends in Molecular Medicine. 2005. doi:10.1016/j.molmed.2005.08.004
- 2Sosne G, et al. "Thymosin beta 4 and the eye: the journey from bench to bedside" Expert Opinion on Biological Therapy. 2016. doi:10.1517/14712598.2016.1227780
- 3Crockford D, et al. "Thymosin β4: structure, function, and biological properties supporting current and future clinical applications" Annals of the New York Academy of Sciences. 2010. doi:10.1111/j.1749-6632.2010.05492.x
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All products on this site are for research and development use only. Products are not for human consumption of any kind. The statements made on this website have not been evaluated by the US Food and Drug Administration or the European Medicines Agency. Products are not intended to diagnose, treat, cure, or prevent any disease.
