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This product is intended solely for use as a research chemical in vitro and laboratory experimentation by licensed, qualified professionals.
TB-500
44,99 €
TB-500 is a synthetic analog of Thymosin Beta-4, a naturally occurring 43-amino acid peptide. Researched for its role in cell migration, cytoskeletal regulation, and tissue repair processes. 10mg lyophilized powder, ≥99% purity.
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TB-500—
44,99 €
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HPLC
Mass Spec
≥99% Purity
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Characteristics
| Molecular Formula | C212H350N56O78S |
| CAS | 77591-33-4 |
| Molar Mass | 4963.44 g/mol |
| Synonyms | Thymosin Beta-4 Fragment, Tβ4 |
| Solubility | Soluble in water |
| Organoleptic Profile | White to off-white powder |
| Physical Form | Lyophilized powder |
How does TB-500 work?
TB-500 binds to and sequesters G-actin monomers, regulating actin polymerization and cytoskeletal dynamics. This mechanism is central to cell movement, making TB-500 valuable for research on wound healing, immune cell trafficking, and tissue remodeling.
Studies indicate TB-500 may modulate inflammatory cytokines including TNF-α and IL-6, with implications for research into inflammatory conditions and tissue repair following injury.
Preclinical models have investigated TB-500's potential effects on cardiac tissue, particularly in the context of ischemic injury and vascular function.
Benefits
- Tissue Regeneration: Enhanced tissue repair and regeneration through upregulation of actin protein for cellular migration
- Flexibility & Mobility: Improved flexibility and range of motion observed in preclinical studies
- Anti-Inflammatory: Modulation of inflammatory cytokines including TNF-α and IL-6
- Cardiovascular Research: Potential cardiovascular benefits observed in ischemic injury models
- Recovery Enhancement: Accelerated healing of injuries through promoted wound healing cascades
Side Effects
TB-500 is generally considered safe and well tolerated when used in research settings. However, as with any substance, there is a potential for side effects, particularly when used at high concentrations or for prolonged periods.
- Headache: Possible mild headache reported in some research subjects
- Fatigue: Temporary fatigue during initial study periods
- Injection Site Reactions: Mild reactions at injection site may occur
- Limited Data: Long-term safety profile not fully established
It's important to note that the safety and efficacy of TB-500 for human use have not been fully established, and more research is needed to determine the long-term effects of this peptide complex.
Summary
TB-500 is a synthetic peptide corresponding to the active region of Thymosin Beta-4, a highly conserved protein found in virtually all mammalian cells. First isolated from the thymus gland, it has been identified as a primary actin-sequestering protein.
TB-500 has appeared in over 900 peer-reviewed publications investigating its biological activities in cell migration, wound healing, and inflammatory modulation.
Certificate of Analysis (COA) available upon request. Each batch is tested via HPLC for purity and Mass Spectrometry for identity confirmation.
References
- 1Goldstein AL, et al. "Thymosin β4: actin-sequestering protein moonlights to repair injured tissues" Trends in Molecular Medicine. 2005. doi:10.1016/j.molmed.2005.08.004
- 2Sosne G, et al. "Thymosin beta 4 and the eye: the journey from bench to bedside" Expert Opinion on Biological Therapy. 2016. doi:10.1517/14712598.2016.1227780
- 3Crockford D, et al. "Thymosin β4: structure, function, and biological properties supporting current and future clinical applications" Annals of the New York Academy of Sciences. 2010. doi:10.1111/j.1749-6632.2010.05492.x
Resource
All products on this site are for research and development use only. Products are not for human consumption of any kind. The statements made on this website have not been evaluated by the US Food and Drug Administration or the European Medicines Agency. Products are not intended to diagnose, treat, cure, or prevent any disease.