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MOTS-C
40,00 €
MOTS-C is a mitochondrial-derived peptide encoded by the 12S rRNA gene. Researched for metabolic regulation, exercise mimetic properties, and cellular energy homeostasis. 10mg lyophilized powder, ≥99% purity.
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MOTS-C—
40,00 €
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≥99% Purity
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Characteristics
| Molecular Formula | C77H121N19O22S2 |
| CAS | 1627580-64-6 |
| Molar Mass | 1764.03 g/mol |
| Amino Acid Sequence | MRWQEMGYIFYPRKLR |
| Synonyms | Mitochondrial Open Reading Frame of the 12S rRNA-c |
| Solubility | Soluble in water |
| Organoleptic Profile | White powder |
| Physical Form | Lyophilized powder |
How does MOTS-C work?
MOTS-C is a 16-amino acid peptide encoded within the mitochondrial genome, making it one of a small number of mitochondrial-derived peptides (MDPs). It regulates metabolic homeostasis by activating AMPK and targeting the folate-methionine cycle.
Research demonstrates MOTS-C accumulates in skeletal muscle during exercise and physical stress. It enhances glucose uptake and fatty acid oxidation in muscle tissue, functioning as an exercise mimetic in preclinical models.
MOTS-C also translocates to the nucleus under metabolic stress, where it regulates adaptive nuclear gene expression. This retrograde signaling from mitochondria to nucleus represents a novel regulatory mechanism with implications for aging and metabolic disease research.
References
- 1Lee C, et al. "The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance" Cell Metabolism. 2015. doi:10.1016/j.cmet.2015.02.009
- 2Reynolds JC, et al. "MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis" Nature Communications. 2021. doi:10.1038/s41467-020-20790-0
- 3Kim KH, et al. "Mitochondrial-derived peptides in aging and age-related diseases" GeroScience. 2021. doi:10.1007/s11357-020-00262-5
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All products on this site are for research and development use only. Products are not for human consumption of any kind. The statements made on this website have not been evaluated by the US Food and Drug Administration or the European Medicines Agency. Products are not intended to diagnose, treat, cure, or prevent any disease.
