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This product is intended solely for use as a research chemical in vitro and laboratory experimentation by licensed, qualified professionals.
MOTS-C
49,99 €
MOTS-C is a mitochondrial-derived peptide encoded by the 12S rRNA gene. Researched for metabolic regulation, exercise mimetic properties, and cellular energy homeostasis. 10mg lyophilized powder, ≥99% purity.
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MOTS-C—
49,99 €
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≥99% Purity
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Characteristics
| Molecular Formula | C77H121N19O22S2 |
| CAS | 1627580-64-6 |
| Molar Mass | 1764.03 g/mol |
| Amino Acid Sequence | MRWQEMGYIFYPRKLR |
| Synonyms | Mitochondrial Open Reading Frame of the 12S rRNA-c |
| Solubility | Soluble in water |
| Organoleptic Profile | White powder |
| Physical Form | Lyophilized powder |
How does MOTS-C work?
MOTS-C is a 16-amino acid peptide encoded within the mitochondrial genome, making it one of a small number of mitochondrial-derived peptides (MDPs). It regulates metabolic homeostasis by activating AMPK and targeting the folate-methionine cycle.
Research demonstrates MOTS-C accumulates in skeletal muscle during exercise and physical stress. It enhances glucose uptake and fatty acid oxidation in muscle tissue, functioning as an exercise mimetic in preclinical models.
MOTS-C also translocates to the nucleus under metabolic stress, where it regulates adaptive nuclear gene expression. This retrograde signaling from mitochondria to nucleus represents a novel regulatory mechanism with implications for aging and metabolic disease research.
Benefits
- Metabolic Regulation: Activates AMPK signaling and enhances glucose uptake in skeletal muscle tissue
- Exercise Mimetic: Mimics exercise-induced metabolic adaptations including improved fatty acid oxidation
- Cellular Energy: Regulates mitochondrial function and cellular energy homeostasis
- Insulin Sensitivity: Improves insulin sensitivity and glucose tolerance in preclinical models
- Aging Research: Endogenous levels decline with age, making it valuable for aging and longevity research
Side Effects
MOTS-C is generally considered safe and well tolerated when used in research settings. However, as with any substance, there is a potential for side effects, particularly when used at high concentrations or for prolonged periods.
- Injection Site Reactions: Mild redness or discomfort at the injection site may occur temporarily
- Gastrointestinal Effects: Mild nausea reported in some research subjects
- Hypoglycemia: Potential for reduced blood glucose levels due to metabolic effects
- Limited Clinical Data: Human safety profile not yet fully characterized
It's important to note that the safety and efficacy of MOTS-C for human use have not been fully established, and more research is needed to determine the long-term effects of this peptide complex.
Summary
MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino acid mitochondrial-derived peptide discovered by Dr. Changhan David Lee and colleagues at USC in 2015. It is encoded within the mitochondrial 12S rRNA gene.
MOTS-C is the first mitochondrial-derived peptide shown to regulate metabolic homeostasis systemically. Research has demonstrated its role as a natural exercise mimetic and its potential relevance to metabolic disease and aging.
Certificate of Analysis (COA) available upon request. Each batch is tested via HPLC for purity and Mass Spectrometry for identity confirmation.
References
- 1Lee C, et al. "The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance" Cell Metabolism. 2015. doi:10.1016/j.cmet.2015.02.009
- 2Reynolds JC, et al. "MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis" Nature Communications. 2021. doi:10.1038/s41467-020-20790-0
- 3Kim KH, et al. "Mitochondrial-derived peptides in aging and age-related diseases" GeroScience. 2021. doi:10.1007/s11357-020-00262-5
Resource
All products on this site are for research and development use only. Products are not for human consumption of any kind. The statements made on this website have not been evaluated by the US Food and Drug Administration or the European Medicines Agency. Products are not intended to diagnose, treat, cure, or prevent any disease.